Reishi – Prostrate.

Reishi and prostate health
Randomized clinical trial of an ethanol extract of
Reishi Ganoderma lucidum in men with lower urinary tract
symptoms.
Asian J Androl. 2008; Noguchi M, Kakuma T, Tomiyasu K,
Yamada A, Itoh K, Konishi F, Kumamoto S, Shimizu K, Kondo R, Matsuoka K.
Department of Urology, Kurume University School of Medicine, 67 Asahi-machi,
Kurume, Japan.
To evaluate the safety and
efficacy of an extract of reishi ganoderma lucidum that shows the strongest
5alpha-reductase inhibitory activity among the extracts of 19 edible and
medicinal mushrooms by a double-blind, placebo-controlled, randomized and
dose-ranging study in men with lower urinary tract symptoms (LUTS). In this
trial, we randomly assigned 88 men over the age of 49 years who had
slight-to-moderate LUTS to 12 weeks of treatment with reishi extract (6 mg once
a day) or placebo. The primary outcome measures were changes in the
International Prostate Symptom Score (IPSS) and variables of uroflowmetry.
Reishi extract was effective and significantly superior to placebo for improving
total IPSS. No changes were observed with respect to quality of life scores,
peak urinary flow, mean urinary flow, residual urine, prostate volume, serum
prostate-specific antigen or testosterone levels. Overall treatment was well
tolerated with no severe adverse effects. The extract of reishi was well
tolerated and improved IPSS scores. These results encouraged a further,
large-scale evaluation of phytotherapy for a long duration using the extract of
reishi extract on men with LUTS.

Anti-androgenic activities of Ganoderma lucidum .
J
Ethnopharmacol. 2005. Department of Forest and Forest Products Science, Faculty
of Agriculture, Kyushu University, Fukuoka
The inhibitory effects of methanol
extracts of 19 edible and medicinal mushrooms on 5alpha-reductase activity were
examined. The extract of Ganoderma lucidum Fr. Krast ( Ganodermataceae-  Reishi
) showed the strongest 5alpha-reductase inhibitory activity. The treatment of
the fruit body of reishi or the extract prepared from it significantly inhibited
the testosterone-induced growth of the ventral prostate in castrated rats. These
results showed that reishi might be a useful ingredient for the treatment of
benign prostatic hyperplasia (BPH).

 

Effectiveness

Clinical studies examining the role of reishi mushrooms in the treatment of  prostate cancer are limited. However, the results of an animal-based study  published in the February 2009 issue of “Chemistry & Biodiversity” show that  reishi mushroom compounds may play a role in the treatment of prostate cancer by  inhibiting cancer cell growth. Findings from an another animal study published  in the July 2007 issue of “Bioorganic and Medicinal Chemistry” also found that  reishi mushroom compounds might suppress cell signaling processes involved in  the development of prostate cancer.

 

The main action of this medicinal mushroom? To disrupt androgen receptor activity and restraint cancerous cells spreading.

For the past decades, the medicinal properties of various fungi have been studied by many scientists. One important fungi characteristic is its ability to fight cancer cell in several ways. However most research concentrated on how fungi affect our immunity.

A new study

In this research, Dr. Ben-Zion Zaidman studied how fungi fight cancer from within the cells. He is supervised by Prof. Eviatar Nevo and Prof. Solomon Wasser from Institute of Evolution (University of Haifa), and Dr. Jamal Mahajna from Migal Galilee Technology Center.

“Until now, researches were based on strengthening immune system with high-molecular-weight polysaccharides which function through specific receptors in cell membranes. Here, we concentrated our research on low-molecular-weight secondary metabolites which can penetrate the cells and act at molecular level from within the cell itself,” explained Dr. Zaidman.

Prostate cancer is one of the most common cancers found in Western countries. According to Dr. Zaidman, prostate cancer is controlled by androgen receptor especially at the early stages. Currently, all medications for prostate cancer treatment work by reducing androgens production or by interfering with their function via androgen receptor.

Positive results

This research started with 201 organic extracts from 68 types of fungi prepared with solvents such as ether, ethyl acetate and ethanol. They used these solvents to select molecules small enough to act from within the cells.

From the 201 extracts, 11 successfully deter androgen receptor activity by more than 40%. Further testing showed that 169 extracts can inhibit growth of cancer cell. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From these active fungi extracts, Ganoderma Lucidum were tested as the most effective in inhibiting androgen receptor and controlling vital development of cancerous cells. “The results of this research are particularly interesting from a commercial aspect. Potential possibilities exist to establish research and development of bioactive components from Ganoderma Lucidum that could yield an anti-prostate cancer drug,” remarked Dr. Zaidman.

University of Haifa, 2007

Int J Oncol 2004 May; 24(5):1093-9.Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Jiang J, Slivova V, Valachovicoca T, Harvey K, Sliva D. Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA.
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