Reishi – Breast Cancer.

Reishi Mushroom and Breast Cancer                                               

Researchers reporting in the International Journal of Oncology stated that Reishi Mushroom (Latin name Ganoderma lucidum) is a “suitable herb for chemoprevention and chemotherapy of breast cancer.” That is a very strong statement coming from a prestigious cancer journal. The authors made the statement in the most recent of 51 studies on the effects of Reishi Mushroom Extract on cancer.  Other research has confirmed the effect on breast cancer as well as prostate cancer.  Several mechanisms appear to be at play.  Reishi Mushroom also exerts a powerfully beneficial effect on the immune system.

 

Breast cancer-related effects of eating mushrooms

A 2008 case-control study of 1,009 Chinese breast cancer patients found that mushroom consumption was inversely related to breast cancer risk. A study of Korean breast cancer patients found consumption of mushrooms to be associated with a significantly decreased risk of breast cancer. Another Korean study found that both the daily intake and the average consumption frequency of mushrooms was associated with reduced risk of breast cancer for postmenopausal women.

Many types of mushroom appear to have beneficial effects with respect to breast cancer prevention (although note that some mushrooms are poisonous and others have been shown to strongly promote cancer in the laboratory). The information below concerns mushrooms available in the U.S.

  • White button mushrooms (Agaricus bisporous) are the most commonly sold mushrooms in supermarkets. They are also known as common mushrooms, button mushrooms, white mushrooms, or table mushrooms. Portobello and crimini mushrooms are closely related to white button mushrooms. Of the mushrooms studied, white button mushrooms have among the most powerful proven breast cancer chemopreventive properties, since they have been shown to suppress aromatase activity and estrogen biosynthesis, in addition to inhibiting proliferation of estrogen receptor positive breast cancer cells. Several studies have concluded that diets high in white button mushrooms may lower the risk of estrogen receptor breast cancer, especially in postmenopausal women, by reducing the production of estrogen from androgen in the body.
  • Maitake mushrooms (Grifola frondosa) are sold dried or fresh in upscale supermarkets and specialty markets. Maitake mushrooms have been shown to reduce growth, inhibit angiogenesis, and induce apoptosis of human breast cancer cells in the laboratory. However, a 2009 trial of maitake mushroom supplementation in postmenopausal breast cancer survivors found that, contrary to expectations, the maitake extract had both immune enhancing and immune suppressant effects at various doses.
  • Shiitake mushrooms (Lentinus edodes) are widely available fresh or dried in grocery stores and specialty markets. Shiitake mushrooms have been found to inhibit increases in tumor volume of human breast cancer cells implanted in mice.
  • Reishi mushrooms (Ganoderma lucidum) usually are sold only in powder form in capsules, in liquid extracts and as tea, since they are too bitter and tough to be eaten as food. Reishi mushroom extracts have been shown to inhibit proliferation, adhesion, angiogenesis, migration, and invasion of several types of breast cancer cells. The addition of green tea extract to reishi extract has been shown to have a synergistic effect in the inhibiting adhesion, migration and invasion of estrogen receptor-negative, progesterone receptor-negative (ER-/PR-) breast cancer cells. Reishi extract has been shown to be effective in inhibiting inflammatory breast cancer progression, one of the few foods to have demonstrated suppressive impact on this form of the disease. While reishi mushroom extracts have been shown to have anti-cancer activities against ER+/PR+ breast cancer cells, they have also been shown to have estrogenic properties. Therefore, we would advise those at high risk for breast cancer and those with estrogen-receptor positive breast cancer against consuming reishi.

 

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3 Comments (+add yours?)

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    Mar 02, 2012 @ 11:18:14

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